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Brain Res. 1987 Mar 3;405(1):196-8.

Carbachol-induced EEG 'theta' activity in hippocampal brain slices.

Abstract

Application of the cholinergic agonist carbachol (50 microM) produced theta-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus. Atropine sulfate (50 microM) antagonized the carbachol-induced theta-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow-wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions.

PMID:
3567594
DOI:
10.1016/0006-8993(87)91009-2
[Indexed for MEDLINE]

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