Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial

Sirimon Reutrakul; Pamela Martyn-Nemeth; Lauretta Quinn; Brett Rydzon; Medha Priyadarshini; Kirstie K Danielson; Kelly G Baron; Jennifer Duffecy

doi:10.1186/s40814-022-01076-2

Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial

Pilot Feasibility Stud. 2022 Jun 4;8(1):119. doi: 10.1186/s40814-022-01076-2.

Authors

Sirimon Reutrakul¹, Pamela Martyn-Nemeth², Lauretta Quinn², Brett Rydzon³, Medha Priyadarshini³, Kirstie K Danielson³, Kelly G Baron^{4

5}, Jennifer Duffecy⁶

Affiliations

¹ Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 835 S. Wolcott, Suite E625, Chicago, IL, 60612, USA. sreutrak@uic.edu.
² Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois at Chicago, 845 S. Damen, Chicago, IL, 60612, USA.
³ Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 835 S. Wolcott, Suite E625, Chicago, IL, 60612, USA.
⁴ Division of Public Health, Department of Family and Preventive Medicine, The University of Utah, 375 Chipeta Way, Salt Lake City, USA.
⁵ Departments of Psychology and Psychiatry, The University of Utah, 501 Chipeta Way, Salt Lake City, UT, 84108, USA.
⁶ Department of Psychiatry, University of Illinois at Chicago, 912 S. Wood Street, Chicago, IL, 60612, USA.

Abstract

Objectives: Women with a history of gestational diabetes (GDM) are at 7-fold increase in the risk of developing diabetes. Insufficient sleep has also been shown to increase diabetes risk. This study aimed to explore the feasibility of a sleep extension in women with a history of GDM and short sleep, and effects on glucose metabolism.

Methods: Women age 18-45 years with a history of GDM and actigraphy confirmed short sleep duration (<7 h/night) on weekdays were randomized at a ratio of 1 control (heathy living information) to 2 cases (6 weeks of "Sleep-Extend" intervention: use of a Fitbit, weekly digital content, and weekly coaching to increase sleep duration). An oral glucose tolerance test (OGTT), 7-day actigraphy recording, and questionnaires were obtained at baseline and 6 weeks. Mean differences between baseline and end-of-intervention parameters were compared using independent samples t-tests.

Results: Mean (SD) sleep duration increased within the Sleep-Extend group (n=9, +26.9 (42.5) min) but decreased within the controls (n=5, - 9.1 (20.4) min), a mean difference (MD) of 35.9 min (95% confidence interval (CI) - 8.6, 80.5). Fasting glucose increased, but less in Sleep-Extend vs. control groups (1.6 (9.4) vs 10.4 (8.2) mg/dL, MD - 8.8 mg/dL (95% CI - 19.8, 2.1), while 2-h glucose levels after an OGTT did not differ. Compared to controls, Sleep-Extend had decreased fatigue score (MD - 10.6, 95%CI - 20.7, - 0.6), and increased self-report physical activity (MD 5036 MET- minutes/week, 95%CI 343, 9729. Fitbit compliance and satisfaction in Sleep-Extend group was high.

Conclusion: Sleep extension is feasible in women with a history of GDM, with benefits in fatigue and physical activity, and possibly glucose metabolism. These data support a larger study exploring benefits of sleep extension on glucose metabolism in these high-risk women.

Trial registration: ClinicalTrials.gov , NCT03638102 (8/20/2018).

Keywords: Gestational diabetes; Glucose; Short sleep; Sleep duration; Sleep extension.

Associated data

ClinicalTrials.gov/NCT03638102

Abstract

Associated data

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