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Nature. 1987 Apr 9-15;326(6113):563-7.

Tests of the helix dipole model for stabilization of alpha-helices.

Abstract

Charged groups play a critical role in the stability of the helix formed by the isolated C-peptide (residues 1-13 of ribonuclease A) in aqueous solution. One charged-group effect may arise from interactions between charged residues at either end of the helix and the helix dipole. We report here that studies of C-peptide analogues support the helix dipole model, and provide further evidence for the importance of electrostatic interactions not included in the Zimm-Bragg model for alpha-helix formation.

PMID:
3561498
DOI:
10.1038/326563a0
[Indexed for MEDLINE]

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