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Nature. 1978 Aug 24;274(5673):775-80.

Molecular basis of base substitution hotspots in Escherichia coli.

Abstract

In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.

PMID:
355893
[Indexed for MEDLINE]
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