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Biosci Rep. 1986 Nov;6(11):967-72.

Glucose-induced reduction of the sodium content in beta-cell-rich pancreatic islets.

Abstract

The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resulted in 25% reduction of the islet content of sodium. This effect became manifest in the presence of 5 mM glucose, there being no additional reduction with a further increase of glucose to 20 mM. Depression of Na+ activity may partially explain why glucose, under certain conditions, can lower cytoplasmic Ca2+ and even inhibit insulin release.

PMID:
3555640
[Indexed for MEDLINE]
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