New insights into IRE1α activation and function in anti-tumor immunity

Susan E Logue; Adrienne M Gorman; Afshin Samali

doi:10.1083/jcb.202205019

New insights into IRE1α activation and function in anti-tumor immunity

J Cell Biol. 2022 Jun 6;221(6):e202205019. doi: 10.1083/jcb.202205019. Epub 2022 May 11.

Authors

Susan E Logue^{1

2}, Adrienne M Gorman^{3

4

5}, Afshin Samali^{3

4

5}

Affiliations

¹ Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
² CancerCare Manitoba Research Institute, Winnipeg, Manitoba, Canada.
³ Apoptosis Research Centre, National University of Ireland Galway, Galway, Ireland.
⁴ School of Biological and Chemical Sciences, National University of Ireland Galway, Galway, Ireland.
⁵ CÚRAM SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland.

Abstract

Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antigen Presentation*
Dendritic Cells / immunology
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Endoribonucleases* / genetics
Humans
Neoplasms* / immunology
Peptides
Protein Serine-Threonine Kinases* / genetics

Substances

Peptides
ERN1 protein, human
Protein Serine-Threonine Kinases
Endoribonucleases

Abstract

Publication types

MeSH terms

Substances

Grants and funding