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Neurosci Lett. 1987 Mar 20;75(1):43-8.

N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro.

Abstract

Bath-applied N-methyl-D,L-aspartate (NMA) was found to elicit locomotor electromyogram (EMG) activity in ankle flexor and extensor muscles in an in vitro lumbar cord-hindlimb preparation of the newborn rat. The frequency and burst duration of the NMA-induced rhythmic EMG activity varied in a dose-dependent manner. The locomotor activity was also observed in a mid sagittally split lumbar spinal preparation, in which the frequency was much lower. It is concluded that spinal neurones with N-methyl-D-aspartate (NMDA) receptors are involved in producing locomotor activity in the rat and that each spinal half can generate hindlimb locomotion on the ipsilateral side.

PMID:
3554010
DOI:
10.1016/0304-3940(87)90072-3
[Indexed for MEDLINE]

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