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Ann Clin Res. 1986;18(5-6):297-303.

Activation of c-ras oncogenes by mutations and amplification.

Abstract

About 15% of all human tumours, including carcinomas, sarcomas, melanomas and leukaemias, contain c-ras oncogenes, which can be detected by a variety of methods. The activating lesion in the c-ras oncogenes is most often a point mutation affecting certain critical amino acid residues of its protein product. The clinical significance of c-ras oncogenes is not yet clear.

PMID:
3551775
[Indexed for MEDLINE]

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