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Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.
Naclerio GA, Abutaleb NS, Onyedibe KI, Karanja C, Eldesouky HE, Liang HW, Dieterly A, Aryal UK, Lyle T, Seleem MN, Sintim HO. Naclerio GA, et al. J Med Chem. 2022 May 12;65(9):6612-6630. doi: 10.1021/acs.jmedchem.1c02034. Epub 2022 Apr 28. J Med Chem. 2022. PMID: 35482444 Free PMC article.
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS. Ma Z, et al. J Med Chem. 2022 Mar 24;65(6):4481-4495. doi: 10.1021/acs.jmedchem.1c02045. Epub 2022 Feb 17. J Med Chem. 2022. PMID: 35175750 Free PMC article.
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, Kim SY, Brown KP, Marchetti C, Hess J, Di Pietro O, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Acebrón-García-de-Eulate M, et al. J Med Chem. 2022 Feb 10;65(3):2149-2173. doi: 10.1021/acs.jmedchem.1c01684. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080396 Free PMC article.
57 results