Vortex vein decompression and/or partial thickness sclerectomies were performed on 6 eyes of 4 patients with uveal effusion syndrome. Vortex vein decompression was undertaken in 3 eyes and was followed by retinal re-attachment in two. Multiple sclerectomies were undertaken in 4 eyes of 3 patients; an initial reduction of sub-retinal fluid occurred in all eyes and retinal re-attachment followed in two. There were no complications following the procedure. The response to surgery in these eyes suggests that the approach is justified and provides further evidence that a scleral abnormality is the underlying cause of uveal effusion syndrome.