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Biochem Biophys Res Commun. 1987 Feb 13;142(3):893-7.

The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study.

Abstract

Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino group of L-aspartate and a terminal phosphate oxygen of carbamoylphosphate.

PMID:
3548720
DOI:
10.1016/0006-291x(87)91497-5
[Indexed for MEDLINE]

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