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Biochem Biophys Res Commun. 1987 Feb 13;142(3):680-7.

2,3-Bisphosphoglycerate protects mitochondrial and cytosolic proteins from proteolytic inactivation.

Abstract

2,3-bisphosphoglycerate at physiological concentration similar to that found in many tissues protects effectively ornithine transcarbamoylase (OTC) from proteolytic inactivation by broken lysosomes. 2,3-bisphosphoglycerate protects also many other mitochondrial and cytosolic proteins, such as glutamate dehydrogenase (GDH) an glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from proteolysis by broken lysosomes and other proteases. It is, thus, suggested that 2,3-bisphosphoglycerate may play an important role in the control of the degradative rates of some proteins, which may explain its high concentration in certain cells.

PMID:
3548716
DOI:
10.1016/0006-291x(87)91468-9
[Indexed for MEDLINE]

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