Abstract
Purified lipopolysaccharide of Escherichia coli produced specific antibody when injected intraperitoneally or given to rats orally. Either route of immunization did not prevent ascending pyelonephritis in a diabetic rat model. The use of purified LPS excludes the potential contribution of other virulence factors of E. coli as protective antigens in the prevention of ascending pyelonephritis and confirms that anti-lipopolysaccharide antibody is not protective for ascending pyelonephritis.
MeSH terms
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Administration, Oral
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Animals
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Antibodies, Bacterial / biosynthesis
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Diabetes Mellitus, Experimental / complications*
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Escherichia coli / immunology*
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Escherichia coli Infections / complications
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Escherichia coli Infections / prevention & control*
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Immunization
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Injections, Intraperitoneal
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Lipopolysaccharides / administration & dosage
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Lipopolysaccharides / immunology*
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Pyelonephritis / complications
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Pyelonephritis / prevention & control*
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Rats
Substances
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Antibodies, Bacterial
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Lipopolysaccharides