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J Gen Microbiol. 1986 Jun;132(6):1565-74.

Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung.

Abstract

Six discrete protease activities were recovered from the supernatant broth of Legionella pneumophila cultures by ion-exchange chromatography. One of these demonstrated in vitro activity against collagen, casein and gelatin. When administered into the lungs of guinea-pigs this protease elicited lesions which were pathologically similar to those seen in clinical and experimentally induced Legionnaires' disease.

PMID:
3543209
DOI:
10.1099/00221287-132-6-1565
[Indexed for MEDLINE]

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