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FEBS Lett. 1986 Nov 10;208(1):84-8.

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes.

Abstract

A serine esterase called granzyme A, which is specifically expressed in cytolytic lymphocytes has been characterized. It is a disulfide-linked dimer and exhibits a trypsin-like specificity cleaving best after Arg. N-terminal sequence analysis revealed that granzyme A is identical to a protease recently predicted from a cloned CTL-specific gene.

PMID:
3533635
DOI:
10.1016/0014-5793(86)81537-x
[Indexed for MEDLINE]
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