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Proc Natl Acad Sci U S A. 1986 May;83(10):3391-4.

Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome.

Abstract

A 4-kilobase DNA fragment carried by a recombinant lambda gt11 bacteriophage appears to contain most of the coding information for the 145-kDa subunit of the Saccharomyces cerevisiae mitochondrial RNA polymerase. The RPO41 gene is located on chromosome VI, as determined by hybridization to electrophoretically separated yeast chromosomes. Hybridization and gene disruption/replacement experiments show that the RPO41 gene exists in a single copy and that its product is required for transcription and maintenance of the mitochondrial genome.

PMID:
3517858
PMCID:
PMC323519
DOI:
10.1073/pnas.83.10.3391
[Indexed for MEDLINE]
Free PMC Article

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