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Epilepsy Res. 1987 Sep;1(5):302-5.

Effects of flunarizine on Metrazol-induced seizures in developing rats.

Author information

1
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.

Abstract

Antimetrazol action of flunarizine (5, 10, 20 and 40 mg/kg i.p.) was tested during ontogenesis on male Wistar rats aged 7, 12, 18, 25 and 90 days. The latencies and incidences of jerks, minimal Metrazol seizures and major Metrazol seizures remained unchanged by flunarizine in all age groups. A specific action (an abolition of the tonic phase of major seizures) was seen throughout the development and was reflected in lower scores of seizures.

PMID:
3504406
DOI:
10.1016/0920-1211(87)90006-4
[Indexed for MEDLINE]

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