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J Ocul Pharmacol. 1986 Fall;2(4):371-8.

Bioavailability and penetration of topical amphotericin B in the anterior segment of the rabbit eye.

Author information

1
Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Abstract

The penetration of topical amphotericin B was studied in Dutch-belted rabbits using bioassay and radioassay techniques. Seven percent of total amphotericin B in the corneas, as measured by recovered 14-C, and 5% in the aqueous was in a bioactive form. Drug was not detectable by bioassay after single drop administration but after a loading dose approach, drug was present in therapeutic amounts. In inflamed corneas, a pass-through effect was noted with higher levels initially but rapid fall-off subsequently.

PMID:
3503121
DOI:
10.1089/jop.1986.2.371
[Indexed for MEDLINE]

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