Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome

Cancer Genet. 2022 Apr:262-263:53-56. doi: 10.1016/j.cancergen.2022.01.001. Epub 2022 Jan 5.
No abstract available

Keywords: DICER1; Mosaic; Pathogenic; RNase IIIb; Sertoli-Leydig.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DEAD-box RNA Helicases* / genetics
  • Female
  • Humans
  • Mutation
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / pathology
  • Ribonuclease III* / genetics
  • Sertoli-Leydig Cell Tumor* / genetics
  • Sertoli-Leydig Cell Tumor* / pathology

Substances

  • DICER1 protein, human
  • Ribonuclease III
  • DEAD-box RNA Helicases

Supplementary concepts

  • Androblastoma of ovary