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Somat Cell Mol Genet. 1987 Nov;13(6):679-84.

Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17.

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  • 1Tokyo Women's Medical College, Japan.

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21-q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acute promyelocytic leukemia.

PMID:
3499671
[PubMed - indexed for MEDLINE]
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