Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration

Osvaldo P Almeida; Annemiek Dols; Machteld A J T Blanken; Soham Rej; Hilary P Blumberg; Luca Villa; Brent P Forester; Orestes V Forlenza; Ariel Gildengers; Eduard Vieta; Esther Jimenez; Benoit Mulsant; Sigfried Schouws; Shangying Tsai; Nicole C M Korten; Ashley Sutherland; Farren B S Briggs; Leon Flicker; Lisa T Eyler; Martha Sajatovic

doi:10.1016/j.jagp.2021.12.006

Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration

Am J Geriatr Psychiatry. 2022 Jun;30(6):727-732. doi: 10.1016/j.jagp.2021.12.006. Epub 2021 Dec 11.

Authors

Osvaldo P Almeida¹, Annemiek Dols², Machteld A J T Blanken², Soham Rej³, Hilary P Blumberg⁴, Luca Villa⁴, Brent P Forester⁵, Orestes V Forlenza⁶, Ariel Gildengers⁷, Eduard Vieta⁸, Esther Jimenez⁸, Benoit Mulsant⁹, Sigfried Schouws², Shangying Tsai¹⁰, Nicole C M Korten², Ashley Sutherland¹¹, Farren B S Briggs¹², Leon Flicker¹³, Lisa T Eyler¹⁴, Martha Sajatovic¹⁵

Affiliations

¹ Medical School (OPA), University of Western Australia, Perth, Australia. Electronic address: osvaldo.almeida@uwa.edu.au.
² GGZ inGeest, Amsterdam UMC (AD, MAJTB, SS, NCMK), VU Medical Center, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
³ Lady Davis Institute (SR), Jewish General Hospital, McGill University, Montreal, Canada.
⁴ Department of Psychiatry (HPB, LV), Yale School of Medicine, New Haven, CT.
⁵ Division of Geriatric Psychiatry, McLean Hospital (BPF), Belmont, Massachusetts, USA and Harvard Medical School, Boston, MA.
⁶ Laboratory of Neuroscience (LIM-27) (OVF), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
⁷ Department of Psychiatry (AG), University of Pittsburgh School of Medicine, Pittsburgh, PA.
⁸ Bipolar and Depressive Disorders Unit (EV, EJ), Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
⁹ Department of Psychiatry (BM), University of Toronto, Center for Addiction & Mental Health, Toronto, Canada.
¹⁰ Department of Psychiatry (ST), School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
¹¹ Department of Psychiatry (AS, LTE), University of California San Diego, San Diego, CA.
¹² Department of Population and Quantitative Health Sciences (FBSB), Case Western Reserve University School of Medicine, Cleveland, OH.
¹³ WA Centre for Health & Ageing, Medical School (LF), University of Western Australia, Perth, Australia.
¹⁴ Department of Psychiatry (AS, LTE), University of California San Diego, San Diego, CA; Desert-Pacific Mental Illness Research Education and Clinical Center (LTE), VA San Diego Healthcare System, San Diego, CA.
¹⁵ Case Western Reserve University School of Medicine (MS), University Hospitals Cleveland Medical Center, Cleveland, OH.

PMID: 34980553
DOI: 10.1016/j.jagp.2021.12.006

Abstract

Objectives: To compare the prevalence of physical morbidities among men and women with older adult bipolar disorder (OABD), and men with and without OABD.

Methods: Cross-sectional analysis of the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) database and non-OABD data from the Health in Men Study. OABD defined as bipolar disorder among adults aged greater than or equal to 50 years. Outcomes of interest were diseases affecting the cardiovascular, respiratory, gastrointestinal, renal, musculoskeletal and endocrinological systems.

Results: We examined 1407 participants with OABD aged 50-95 years, of whom 787 were women. More women than men showed evidence of morbidities affecting the respiratory, gastrointestinal, musculoskeletal and endocrinological systems. More men with than without OABD showed evidence of cardiovascular, renal and endocrinological diseases.

Conclusion: GAGE-BD data showed that physical morbidities affect more women than men with OABD, and more men with than without OABD. The underlying reasons for these differences require clarification.

Keywords: Bipolar disorder; Medical morbidity; Men; Old age; Physical illness; Sex; Women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aging
Bipolar Disorder* / epidemiology
Cross-Sectional Studies
Databases, Factual
Female
Humans
Male
Prevalence