Format

Send to

Choose Destination
Nature. 1987 Jul 30-Aug 5;328(6129):395-9.

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells.

Abstract

A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

PMID:
3497349
DOI:
10.1038/328395a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center