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Am J Med. 1987 Jan;82(1):129-31.

Disseminated cryptococcal infection in a patient with hypogammaglobulinemia and normal T cell functions.


The immunologic status of a patient with disseminated cryptococcosis and no underlying predisposing factor was evaluated. The proportions and numbers of T cells, T cell subsets, B cells and proliferative responses to mitogens and soluble antigens, including cryptococcal antigen, were comparable to those in healthy control subjects; however, the patient had moderately severe hypogammaglobulinemia. The patient continues to do well clinically with intravenous gammaglobulin and antifungal therapy. This study suggests that antibodies might also play a role in the defense against cryptococcal antigen.

[Indexed for MEDLINE]

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