Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1986 Apr 14;136(1):94-101.

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages.

Abstract

We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages. Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10(-8) M. While indomethacin decreased tumor necrosis factor induced PGE2 production, this cyclooxygenase inhibitor augmented tumor necrosis factor induced interleukin-1 production. Our data suggests that tumor necrosis factor may be an important immunopotentiating agent in addition to its previously described cytolytic and metabolic activities.

PMID:
3486658
DOI:
10.1016/0006-291x(86)90881-8
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for MLibrary (Deep Blue)
Loading ...
Support Center