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Hepatogastroenterology. 1987 Aug;34(4):164-70.

Gastroprotective and ulcer healing effects of solon, a synthetic flavonoid derivative of sophoradin.

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1
Institute of Physiology, Academy of Medicine, Krakow, Poland.

Abstract

Solon, a synthetic isoprenyl flavonoid derived from sophoradin isolated from the root of an ancient Chinese plant, administered orally to rats, prevented, dose-dependently, the formation of acute gastric lesions produced by absolute ethanol given orally. Solon also enhanced the healing of chronic gastric and duodenal ulcerations induced by the serosal application of acetic acid. The gastroprotective action of Solon was probably mediated by increased mucosal content of prostaglandins (PG) due mainly to the inhibition of 15-OH-prostaglandin dehydrogenase. The ulcer-healing action of Solon was probably related to the stimulation of mucus-alkaline secretion, increased mucosal blood flow and the formation of a protective barrier on the ulcer base.

PMID:
3478294
[Indexed for MEDLINE]
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