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Am J Psychiatry. 1978 Apr;135(4):472-5.

The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study.

Abstract

The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.

PMID:
345827
DOI:
10.1176/ajp.135.4.472
[Indexed for MEDLINE]
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