Treatment of primary infertility in McCune-Albright syndrome: a case report of a successful in vitro fertilization cycle

Rebecca K Chung; Abigail C Mancuso; Jessica D Kresowik

doi:10.1016/j.xfre.2021.05.001

Treatment of primary infertility in McCune-Albright syndrome: a case report of a successful in vitro fertilization cycle

F S Rep. 2021 May 20;2(3):352-356. doi: 10.1016/j.xfre.2021.05.001. eCollection 2021 Sep.

Authors

Rebecca K Chung¹, Abigail C Mancuso², Jessica D Kresowik²

Affiliations

¹ University Hospitals Cleveland Medical Center Division of Reproductive Endocrinology and Infertility, 1000 Auburn Drive, Suite 310, Beachwood, Ohio.
² Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa.

Abstract

Objective: To report a case in which pregnancy and live birth were achieved in an infertile patient with McCune-Albright syndrome via in vitro fertilization (IVF).

Design: Case report.

Setting: University hospital.

Patients: A 29-year-old woman with McCune-Albright syndrome who presented with primary infertility due to ovulatory dysfunction and bilateral tubal blockage.

Interventions: In vitro fertilization without unilateral oophorectomy.

Main outcome measures: Live birth after IVF treatment.

Results: Fresh IVF stimulation and bilateral oocyte retrieval yielded 12 oocytes and 4 top quality embryos. Fresh single embryo transfer did not result in pregnancy. Live birth occurred after the second frozen embryo transfer cycle.

Conclusions: In vitro fertilization can lead to ongoing pregnancy in infertile patients with McCune-Albright syndrome without requiring unilateral oophorectomy.

Keywords: McCune-Albright syndrome; infertility; in vitro fertilization.