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Trans R Soc Trop Med Hyg. 1987;81(5):768-70.

Immunity to Acanthamoeba culbertsoni: experimental studies with Acanthamoeba and control antigen preparations.

Author information

1
Department of Clinical Parasitology, Robert-Koch-Institute, Berlin, German Federal Republic.

Abstract

Mice were intranasally immunized with living and killed Acanthamoeba as well as culture supernatant, living Toxoplasma and BCG, and challenged with pathogenic A. culbertsoni strain A-1. The best protection was achieved with killed amoebae of the same strain. A high rate of mortality was observed in immunized mice treated with immunosuppressives and challenged with A. culbertsoni A-1. The significance of the results in relation to environmental human infection is discussed.

PMID:
3449996
DOI:
10.1016/0035-9203(87)90026-5
[Indexed for MEDLINE]

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