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Biochem Genet. 1987 Aug;25(7-8):563-8.

Assignment of the gene for adenine phosphoribosyltransferase on the genetic map of mouse chromosome 8.

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Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk.


Two electrophoretic variants of adenine phosphoribosyltransferase (APRT) were identified in a population of wild mice (Mus musculus bactrianus). Breeding tests demonstrated that the APRT variants are under the control of two alleles at an autosomal locus designated Aprt. We have examined the linkage relationships between Aprt and the markers of chromosome 8 including esterase-1 and the centromere. The recombination distance between the centromere and Aprt is 44 +/- 7 cM, and that between Es-1 and Aprt is 25 +/- 2 cM, i.e., the probable order of the markers examined is cen-Es-1-Aprt on chromosome 8.

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