Coronaviruses construct an interconnection way with ERAD and autophagy

Future Microbiol. 2021 Sep;16(14):1135-1151. doi: 10.2217/fmb-2021-0044. Epub 2021 Sep 1.

Abstract

Coronaviruses quickly became a pandemic or epidemic, affecting large numbers of humans, due to their structural features and also because of their impacts on intracellular communications. The knowledge of the intracellular mechanism of virus distribution could help understand the coronavirus's proper effects on different pathways that lead to the infections. They protect themselves from recognition and damage the infected cell by using an enclosed membrane through hijacking the autophagy and endoplasmic reticulum-associated protein degradation pathways. The present study is a comprehensive review of the coronavirus strategy in upregulating the communication network of autophagy and endoplasmic reticulum-associated protein degradation.

Keywords: COVID-19; ERAD; SARS-CoV-2; autophagy; coronaviruses; viral infection.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / pharmacology
  • Autophagosomes / metabolism
  • Autophagosomes / virology
  • Autophagy* / drug effects
  • COVID-19 / metabolism
  • COVID-19 / pathology
  • COVID-19 / virology
  • COVID-19 Drug Treatment
  • Coronavirus / classification
  • Coronavirus / pathogenicity*
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / metabolism
  • Coronavirus Infections / pathology
  • Coronavirus Infections / virology
  • Endoplasmic Reticulum-Associated Degradation* / drug effects
  • Humans
  • SARS-CoV-2 / pathogenicity
  • Virus Replication / drug effects

Substances

  • Antiviral Agents