Hemolysis after subcutaneous deoxycholic acid overdose

Abigail Sharpe; Mary O'Keefe; Katie Windsor; Jillian Theobald; Ryan Feldman

doi:10.1016/j.ajem.2021.08.021

Hemolysis after subcutaneous deoxycholic acid overdose

Am J Emerg Med. 2022 Feb:52:268.e1-268.e2. doi: 10.1016/j.ajem.2021.08.021. Epub 2021 Aug 15.

Authors

Abigail Sharpe¹, Mary O'Keefe², Katie Windsor³, Jillian Theobald², Ryan Feldman²

Affiliations

¹ Wisconsin Poison Control Center, 999 N 92nd Street, Suite 600, Wauwatosa, WI 53226, United States of America. Electronic address: arsharpe@wisc.edu.
² Wisconsin Poison Control Center, 999 N 92nd Street, Suite 600, Wauwatosa, WI 53226, United States of America.
³ Concordia University Wisconsin School of Pharmacy; 12800 N Lake Shore Drive, Mequon, WI, 53097, United States of America.

PMID: 34456101
DOI: 10.1016/j.ajem.2021.08.021

Abstract

This report describes a case of hemolysis in a patient injecting deoxycholic acid and benzyl alcohol for aesthetic benefit without medical supervision. The concentration and dose injected by the patient resulted in a 10-fold overdose of deoxycholic acid in comparison to the FDA-recommended dosing for the approved indication. Providers should be aware of medically unsupervised use of DCA and other injectables and the potential risks associated with this practice.

Keywords: Deoxycholic acid; Hemolysis; Overdose.

Publication types

Case Reports

MeSH terms

Adult
Cholagogues and Choleretics / poisoning*
Deoxycholic Acid / poisoning*
Hemolysis / drug effects*
Humans
Injections, Subcutaneous
Male

Substances

Cholagogues and Choleretics
Deoxycholic Acid