Investigation of dynamic functional connectivity of the source reconstructed epileptiform discharges in focal epilepsy: A graph theory approach

Objective: The aim of the present study is to investigate with noninvasive methods the modulation of dynamic functional connectivity during interictal epileptiform discharge (IED).

Method: We reconstructed the cortical source of the EEG recorded IED of 17 patients with focal epilepsy. We then computed dynamic connectivity using the time resolved phase locking value (PLV). We derived graph theory indices (i.e. degree, strength, local efficiency, clustering coefficient and global efficiency). Finally, we selected the atlas node with the maximum activation as the IED cortical source investigating the graph indices dynamics in theta, alpha, beta and gamma frequency bands.

Results: We observed IED-locked modulations of the graph indexes depending on the frequency bands. We detected a modulation of the strength, clustering coefficient, local and global efficiency both in theta and in alpha bands, which also displayed modulations of the degree index. In the beta band only the global efficiency was modulated by the IED, while no effects were detected in the gamma band. Finally, we found a correlation between alpha and theta local efficiency, as well as alpha global efficiency, and the epilepsy duration.

Significance: Our findings suggest that the neural synchronization is not limited to the IED cortical source, but implies a phase synchronization across multiple brain areas. We hypothesize that the aberrant electrical activity originating from the IED locus is spread amongst the other network nodes throughout the low frequency bands (i.e. theta and alpha). Moreover, IED-dependent increase in the global efficiency indicates that the IED interfere with the whole network functioning. We finally discussed possible application of this methodology for future investigation.