Vancomycin entry into lung lymph in sheep

Antimicrob Agents Chemother. 1987 Nov;31(11):1689-91. doi: 10.1128/AAC.31.11.1689.

Abstract

The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Female
  • Lung / metabolism*
  • Lymph / metabolism*
  • Permeability
  • Protein Binding
  • Sheep
  • Vancomycin / pharmacokinetics*

Substances

  • Blood Proteins
  • Vancomycin