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Mech Ageing Dev. 1987 Nov;41(1-2):29-38.

Distribution of superoxide dismutase, glutathione peroxidase and catalase in developing rat brain.

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Department of Clinical Neurological Sciences, Victoria Hospital, University of Western Ontario, London, Canada.


This study was carried out to assess the developmental pattern of copper- and zinc-containing superoxide dismutase (CuZnSOD), manganese-containing superoxide dismutase (MnSOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activity in rat brain. The enzymes studied were assayed in different brain regions (cerebral cortex, striatum, cerebellum and brainstem) and enzyme values were corrected for erythrocyte contamination. The cerebral ontogenetic pattern of these enzymes is characterized by increasing CuZnSOD activity, a progressive decrease in CAT activity and, after an initial 10-day fall, increasing GSH-Px activity. The activity of MnSOD appeared to be quite stable up to 40 weeks of age. Similar and comparable changes were seen in all brain regions studied.

[Indexed for MEDLINE]

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