Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study

Hypertension. 2021 Sep;78(3):591-603. doi: 10.1161/HYPERTENSIONAHA.120.16667. Epub 2021 Jul 26.

RuiJun Chen^{1

2}, Marc A Suchard^{3

4}, Harlan M Krumholz^{5

6}, Martijn J Schuemie^{3

7}, Steven Shea⁸, Jon Duke⁹, Nicole Pratt¹⁰, Christian G Reich¹¹, David Madigan¹², Seng Chan You¹³, Patrick B Ryan¹, George Hripcsak^{1

14}

¹ Department of Biomedical Informatics, Columbia University Irving Medical Center, New York (R.C., P.B.R., G.H.).
² Department of Translational Data Science and Informatics, Geisinger, Danville, PA (R.C.).
³ Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles (M.A.S., M.J.S.).
⁴ Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California, Los Angeles (M.A.S.).
⁵ Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT (H.M.K.).
⁶ Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (H.M.K.).
⁷ Epidemiology Analytics, Janssen Research and Development, Titusville, NJ (M.J.S.).
⁸ Department of Medicine (S.S.), Columbia University, New York.
⁹ Georgia Tech Research Institute, Georgia Tech College of Computing, Atlanta (J.D.).
¹⁰ Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, Australia (N.P.).
¹¹ Real World Solutions, IQVIA, Cambridge, MA (C.G.R.).
¹² Department of Statistics (D.M.), Columbia University, New York.
¹³ Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea (S.C.Y.).
¹⁴ Medical Informatics Services, New York-Presbyterian Hospital (G.H.).

Abstract

[Figure: see text].

Keywords: angiotensin receptor; angiotensin receptor blocker; cardiovascular outcomes; hypertension; safety.