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J Clin Psychopharmacol. 1987 Dec;7(6):401-5.

Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology.

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Department of Neuroscience, University of North Dakota School of Medicine, Grand Forks.


Two patients with infantile autism by DSM-III criteria and with atypical bipolar symptomatology were treated with lithium carbonate. Both children demonstrated a significant response with levels above 1.0mEq/liter. Factors that may be useful in discovering patients with autism who may respond to lithium treatment include a family history of bipolar illness; extreme hyperactivity not responsive to a stimulant; a definite cyclic component to symptomatic behaviors; sustained laughter, irritability, or giddiness that is not stereotypic; and/or the presence of many or all of the symptom criteria for bipolar disorder.

[Indexed for MEDLINE]

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