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Biomaterials. 1987 Nov;8(6):423-6.

Adhesive colonization of biomaterials and antibiotic resistance.

Author information

1
Section of Orthopedic Surgery, Wake Forest University Medical Center, Winston-Salem, NC 27103.

Abstract

This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermis were well above normal.

PMID:
3427140
DOI:
10.1016/0142-9612(87)90077-9
[Indexed for MEDLINE]

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