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Biochemistry. 1987 Dec 1;26(24):7870-5.

The DNA sequence of the human beta-globin region is strongly biased in favor of long strings of contiguous purine or pyrimidine residues.

Author information

1
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015.

Abstract

The DNA sequence of the human beta-globin region, comprising over 67 kilobase pairs, has been analyzed for the occurrence of strings of contiguous purine or pyrimidine residues. Tracts of 10 or more contiguous residues are found 4 times more frequently than would be expected with a random distribution of bases, so that a long string occurs at an average of every 250 base pairs. A survey of six other human gene sequences, totaling 86 kilobase pairs, shows a remarkably similar result. No such overrepresentation of contiguous purine or pyrimidine residues is found in the bacteriophages lambda or T7.

PMID:
3427110
DOI:
10.1021/bi00398a050
[Indexed for MEDLINE]

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