A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease

Zheng Fu; Jian Wang; Zheng Wang; Ying Sun; Jian Wu; Yongchen Zhang; Xingxiang Liu; Zhen Zhou; Likun Zhou; Chen-Yu Zhang; Yongxiang Yi; Xinyi Xia; Lin Wang; Xi Chen

doi:10.1038/s41421-021-00289-8

A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease

Cell Discov. 2021 Jul 6;7(1):48. doi: 10.1038/s41421-021-00289-8.

Authors

Zheng Fu^#¹, Jian Wang^#², Zheng Wang^#³, Ying Sun^#¹, Jian Wu^#⁴, Yongchen Zhang⁵, Xingxiang Liu⁶, Zhen Zhou¹, Likun Zhou¹, Chen-Yu Zhang⁷, Yongxiang Yi⁸, Xinyi Xia^{9

10

11}, Lin Wang¹², Xi Chen¹³

Affiliations

¹ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
² Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁴ COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
⁵ Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁶ Huai'an Fourth Hospital, Huai'an, Jiangsu, China.
⁷ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. cyzhang@nju.edu.cn.
⁸ Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. ian0216@126.com.
⁹ COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China. xiaxynju@nju.edu.cn.
¹⁰ Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, Wuhan, Hubei, China. xiaxynju@nju.edu.cn.
¹¹ Joint Expert Group for COVID-19, Wuhan Huoshenshan Hospital, Wuhan, Hubei, China. xiaxynju@nju.edu.cn.
¹² Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. wang@hust.edu.cn.
¹³ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. xichen@nju.edu.cn.

^# Contributed equally.

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