Early-onset colorectal cancer risk extends to second- and third-degree relatives

Cancer Epidemiol. 2021 Aug:73:101973. doi: 10.1016/j.canep.2021.101973. Epub 2021 Jun 29.

Abstract

Introduction: Family history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown.

Methods: We estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database.

Results: We observed elevated risks beyond RR = 2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively.

Discussion: Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Colorectal Neoplasms* / epidemiology
  • Colorectal Neoplasms* / genetics
  • Family*
  • Genetic Predisposition to Disease*
  • Humans
  • Medical History Taking
  • Pedigree
  • Risk Factors