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Nature. 1988 Sep 1;335(6185):40-5.

Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells.

Author information

1
Smith Kline & French Research Limited, The Frythe, Welwyn, Hertfordshire, UK.

Abstract

Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.

PMID:
3412458
DOI:
10.1038/335040a0
[Indexed for MEDLINE]

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