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J Pharm Sci. 1988 May;77(5):380-2.

Differential metabolism of the enantiomers of primaquine.

Author information

1
Department of Medicinal Chemistry, University of Mississippi, University 38677.

Abstract

When racemic primaquine was administered to rats, the majority of the residual primaquine excreted in urine was found to be the (+)-isomer. Using a liver microsome preparation, there was no selectivity in the metabolism of the (+)- and (-)-isomers; however, a liver fraction containing mitochondria and microsomes did show selectivity. In the latter preparation, there was a marked preference for the conversion of (-)-primaquine to (-)-carboxy-primaquine.

PMID:
3411455
DOI:
10.1002/jps.2600770503
[Indexed for MEDLINE]

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