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FEBS Lett. 1988 Aug 29;236(2):462-6.

Synthetic magainin analogues with improved antimicrobial activity.

Author information

1
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Abstract

Based on modifications to enhance the alpha-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.

PMID:
3410055
DOI:
10.1016/0014-5793(88)80077-2
[Indexed for MEDLINE]
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