Abstract
Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and DNA replication. Vertebrates have two paralogs of PDS5, PDS5A and PDS5B, which have redundant and unique roles in regulating cohesin functions. Herein, we discuss the molecular characteristics and functions of PDS5, as well as the effects of its mutations in the development of diseases and their relevance for novel therapeutic strategies.
Keywords:
PDS5A; PDS5B; cancer; cohesin; cohesinopathy.
MeSH terms
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Animals
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / genetics*
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Cell Cycle Proteins / metabolism
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Conserved Sequence
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DNA Damage
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DNA Repair*
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DNA Replication
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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De Lange Syndrome / genetics*
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De Lange Syndrome / metabolism
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De Lange Syndrome / pathology
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Gene Expression
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Humans
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Mice
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Mice, Knockout
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Models, Molecular
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Nuclear Proteins / chemistry
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Nuclear Proteins / genetics*
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Nuclear Proteins / metabolism
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Protein Structure, Secondary
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / metabolism
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Sister Chromatid Exchange
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Transcription Factors / chemistry
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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Nuclear Proteins
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PDS5 protein, S cerevisiae
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PDS5A protein, human
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PDS5B protein, human
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Saccharomyces cerevisiae Proteins
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Transcription Factors