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Nature. 1988 Aug 18;334(6183):580-5.

Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin.

Author information

1
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Abstract

Tubulin synthesis in animal cells is controlled by an autoregulatory mechanism that modulates the stability of polysome-bound tubulin messenger RNAs. The beta-tubulin RNAs are selectively targeted as substrates for destabilization not through the recognition of specific RNA sequences, but rather through co-translational recognition of the amino-terminal beta-tubulin tetrapeptide after its emergence from the ribosome. This motif is likely to be used in other systems where RNA degradation is coupled to ribosome attachment and translation.

PMID:
3405308
DOI:
10.1038/334580a0
[Indexed for MEDLINE]

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