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FEBS Lett. 1988 Aug 1;235(1-2):173-7.

Mitochondrial targeting sequences. Why 'non-amphiphilic' peptides may still be amphiphilic.

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1
Department of Theoretical Physics, Royal Institute of Technology, Stockholm, Sweden.

Abstract

The notion that mitochondrial targeting peptides form amphiphilic alpha-helices with one apolar and one polar, positively charged face is controversial, since some experimental results seem to imply that non-amphiphilic targeting peptides can also function as import signals. However, the standard methods used to assess the amphiphilicity of a peptide may be misleading, since they do not take the flexibility of the amino acid side chains into account. To demonstrate this, we have developed a new method for calculating the amphiphilicity of helical peptides.

PMID:
3402595
DOI:
10.1016/0014-5793(88)81257-2
[Indexed for MEDLINE]
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