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Doc Ophthalmol. 1988 Mar-Apr;68(3-4):293-304.

Scotopic stimulus/response relations of the B-wave of the electroretinogram.

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Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, MA 02115.


Scotopic b-wave stimulus/response (S/R) functions are abnormal in several human retinal degenerative disorders. However, the mechanisms by which diseases affect the S/R parameters are not yet fully known. Three experiments were done to simulate functional pathologies known to occur in retinal degenerations: 1) attenuated sensitivity of retinal units, 2) loss of rhodopsin, 3) loss of sensitivity with little or no loss of rhodopsin. None of the experimental perturbations of normal function replicated the pattern of S/R abnormalities caused by retinal degenerations. Thus, in the retinal degenerative disorders intrinsic abnormalities of cellular processing must affect the organization of distal retinal function indexed by the b-wave.

[Indexed for MEDLINE]

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