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Vopr Med Khim. 1988 Mar-Apr;34(2):97-9.

[Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency].

[Article in Russian]


Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.

[PubMed - indexed for MEDLINE]
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