Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2149-2167. doi: 10.1161/ATVBAHA.121.315579. Epub 2021 May 13.

Authors

Affiliations

¹ A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (P.R.M., V.T.B., K.O., T.O., H.H.P., S.Y.-H., J.P.L., S.L.-K., M.U.K.).
² Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio (M.B.-L., P.P., M.H.).
³ Now with Genevia Technologies Oy, Tampere, Finland (M.B.-L.).
⁴ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN (P.P.).
⁵ Now with MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, and Broad Institute of MIT and Harvard, Cambridge, MA (S.L.-K.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cardiovascular diseases; endothelial cells; gene expression; macrophages; microRNA.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aorta / metabolism*
Aorta / pathology
Aortic Diseases / genetics*
Aortic Diseases / metabolism
Aortic Diseases / pathology
Atherosclerosis / genetics*
Atherosclerosis / metabolism
Atherosclerosis / pathology
Cells, Cultured
Gene Expression Profiling*
Human Umbilical Vein Endothelial Cells / metabolism
Human Umbilical Vein Endothelial Cells / pathology
Humans
Macrophages / metabolism
Macrophages / pathology
MicroRNAs / genetics*
MicroRNAs / metabolism
Muscle, Smooth, Vascular / metabolism
Muscle, Smooth, Vascular / pathology
Myocytes, Smooth Muscle / metabolism
Myocytes, Smooth Muscle / pathology
Plaque, Atherosclerotic
RNA-Seq
Transcriptome*

Substances

MicroRNAs