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Am J Nephrol. 1988;8(2):85-9.

The importance of sample size in the interpretation of the renal biopsy.

Author information

1
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.

Abstract

The number of abnormal glomeruli present in a renal biopsy can be viewed as a binomial distribution. Recognition of this fact permits a quantitative assessment of the effect of biopsy sample size in renal biopsy interpretation. If the percent of glomerular involvement in a biopsy is used to determine the severity of a focal glomerular lesion, a small biopsy sample size will lead to considerable misclassification of disease severity. In addition, a small biopsy sample size will make the exclusion of focal disease difficult.

PMID:
3394725
DOI:
10.1159/000167563
[Indexed for MEDLINE]

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